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  • Title: Kinetic studies on the interaction of streptokinase and other plasminogen activators with plasminogen and fibrin.
    Author: Fears R, Hibbs MJ, Smith RA.
    Journal: Biochem J; 1985 Jul 15; 229(2):555-8. PubMed ID: 4041182.
    Abstract:
    The activation of Lys-plasminogen to plasmin by streptokinase was promoted by soluble fibrin such that Km was decreased and Vmax. increased. Enhancement was also observed when Glu-plasminogen was the substrate and was shared by the preformed streptokinase-plasminogen activator complex, indicating that the stimulation was not exerted primarily on the rate of active site formation.
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