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  • Title: Prepuberal reproductive defects in neonatal estrogenized male rats.
    Author: Bellido C, Gaytán F, Aguilar R, Pinilla L, Aguilar E.
    Journal: Biol Reprod; 1985 Sep; 33(2):381-7. PubMed ID: 4041525.
    Abstract:
    Intact Wistar male rats injected on Day 1 with 500 micrograms of estradiol benzoate or olive oil were decapitated on Days 15 and 22 or maintained until adulthood to analyze the balanopreputial separation. Other oil or estradiol-treated rats were orchidectomized on Day 15 and decapitated on Day 22. The neonatal estrogenization produced the following reproductive changes prior to puberty: testis, adrenal, and ventral prostate atrophy; increase in the weights of seminal vesicles and epididymis; decrease in testosterone plasma levels; delayed balanopreputial separation; abolition of luteinizing hormone response to orchidectomy; transient increase in prolactin plasma levels; and blockade in seminal and prostate response to orchidectomy.
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