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  • Title: Heat-induced inhibition of DNA synthesis in L5178Y-S cells is reversed by caffeine.
    Author: Kapiszewska M, Szumiel I, Wlodek D.
    Journal: Exp Cell Res; 1985 Sep; 160(1):236-9. PubMed ID: 4043244.
    Abstract:
    Heating L5178Y cells for 15 min at 43 degrees C caused a decrease in [3H]thymidine incorporation, which could be reversed by post-treatment with 0.75 mM caffeine in an L5178Y-S (radiation-sensitive, heat-resistant) but not in an L5178Y-R (radiation-resistant, heat-sensitive) strain. The reversal was accompanied by a sparing effect of the treatment: survival of L5178Y-S cells increased by a factor of 1.5. The effect of combined (heat + caffeine) treatment of L5178Y-R cells was cumulative.
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