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  • Title: Diaphragmatic hernia in the fetus: prenatal diagnosis and outcome in 94 cases.
    Author: Adzick NS, Harrison MR, Glick PL, Nakayama DK, Manning FA, deLorimier AA.
    Journal: J Pediatr Surg; 1985 Aug; 20(4):357-61. PubMed ID: 4045660.
    Abstract:
    Most babies born with congenital diaphragmatic hernia (CDH) die after birth. The natural course of CDH in the human fetus is not known. We found 94 cases of fetal CDH in the records of surgeons and obstetricians surveyed in the United States and Canada. We found the following: (1) prenatal diagnosis of CDH is accurate and current techniques can detect lethal nonpulmonary anomalies and prevent diagnostic errors; (2) despite optimal conventional therapy, most fetuses with detectable CDH will die in the neonatal period (80% mortality); (3) polyhydramnios is both a common prenatal marker for CDH (present in 76% of fetuses) and a predictor for poor clinical outcome (only 11% survived); (4) fetal CDH is a dynamic process--nonsurvivors have larger defects and may have more viscera displaced into the chest at an earlier stage of development. Surgical intervention before birth may be necessary to improve survival of the fetus with CDH and polyhydramnios.
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