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  • Title: Experimental production of arachnoiditis with water-soluble myelographic media.
    Author: Haughton VM, Ho KC, Larson SJ, Unger GF, Correa-Paz F.
    Journal: Radiology; 1977 Jun; 123(3):681-5. PubMed ID: 404664.
    Abstract:
    After myelography with either metrizamide (300mg l/ml) or meglumine iocarmate (280 mg l/ml), mild to severe arachnoid fibrosis was demonstrated radiographically and histologically in primates. Intrathecal injections of metrizamide (170 mg l/ml) or autologous cerebrospinal fluid produced less arachnoiditis. The risk of arachnoiditis is probably minimized by the use of reduced volumes and concentrations of water-soluble media. Controlled studies of arachnoiditis following myelography are probably more reliable in the primate model than in other experimental animals.
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