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  • Title: [Cardiovascular effects of a single injection of fentanyl in dogs under acute experimental conditions].
    Author: Pédrant G, Fabre J, Fogliani S, Ferrali JP, Pomane C, Lacroix E, François G.
    Journal: Ann Anesthesiol Fr; 1979; 20(4):313-7. PubMed ID: 40490.
    Abstract:
    Experimental studies carried out in unselected dogs often face the problem of instabilit of various parameters both in terms of haemodynamics as well as acid-base balance. It is possible, with the injection of a single dose of Fentanyl of 0.35 mg.kg-1 given over a period of ten minutes to obtain, from the 30th minute after the injection, satisfactory cardiovascular stability (confirmed during 120 minutes in 9 dogs and 360 minutes in 2 of them). This haemodynamic state at T + 30 is obtained with a fall in mean blood pressure of -40 per cent, and an increase in peripheral resistance of +38 per cent and stroke volume of +11 per cent. This stability, obtained at the price of a stable normacapnia, correction of any possible metabolic acidosis and maintenance of body temperature, makes it possible to study the cardiovascular effects of certain types of treatment or of induced pathology.
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