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  • Title: Early effects of denervation on isometric and isotonic contractile properties of rat skeletal muscles.
    Author: Gundersen K.
    Journal: Acta Physiol Scand; 1985 Aug; 124(4):549-55. PubMed ID: 4050481.
    Abstract:
    The contractile properties of the fast-twitch m. extensor digitorum longus (EDL) and the slow-twitch m. soleus were examined after 5 days of denervation. An increase in twitch time to peak, twitch half relaxation time and twitch/tetanus ratio was observed. The EDL also showed a moderate decrease in maximal isotonic shortening velocity, which is taken as an indication that the contractile proteins are affected. A fatigue test showed that the EDL became less fatigable and the soleus less fatigue resistant after denervation.
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