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  • Title: Cryptococcal meningitis: presentation as sudden deafness.
    Author: Maslan MJ, Graham MD, Flood LM.
    Journal: Am J Otol; 1985 Sep; 6(5):435-7. PubMed ID: 4050983.
    Abstract:
    A patient presented with a bilateral profound hearing loss of sudden onset following a two-month neurologic illness. Microscopy and culture of cerebrospinal fluid revealed Cryptococcus neoformans. Treatment with amphotericin B and 5-fluorocytosine failed to restore hearing. Auditory brain stem response and electrical promontory stimulation suggest a profound deafness with poor neuronal survival. This is consistent with previous temporal bone histopathology reports in individuals dying of cryptococcal meningitis, suggesting a retrocochlear lesion. It is important to exclude this occult pathologic factor in a patient with the sudden onset of sensorineural deafness prior to embarking upon a course of steroid therapy.
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