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  • Title: [Mode of action at the cellular level of new thiopyrimidines with antimitotic properties].
    Author: Bassleer R, De Paermentier F, Jamoulle JC, Lapière CL.
    Journal: C R Acad Hebd Seances Acad Sci D; 1977 Mar 07; 284(10):859-61. PubMed ID: 405120.
    Abstract:
    New thiopyrimidine derivatives have been synthesized. Among them, several inhibit the multiplication of Chick embryo cells cultivated in vitro: they provoke strong nucleolar alterations, prevent the cells from entering into mitosis and can give rise to cell polyploidisation as to DNA.
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