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  • Title: New glutaramic acid derivatives with potent competitive and specific cholecystokinin-antagonistic activity.
    Author: Makovec F, Chistè R, Bani M, Pacini MA, Setnikar I, Rovati LA.
    Journal: Arzneimittelforschung; 1985; 35(7):1048-51. PubMed ID: 4052139.
    Abstract:
    New glutaramic acid derivatives were evaluated for anti-cholecystokinin (CCK) activity in vitro on guinea pig gallbladder. The compounds are competitive and specific CCK-antagonists, causing a parallel right shift of the cumulative dose-response curve of the agonist. The affinity for the binding site of the CCK-receptor for some of these compounds was hundreds of times higher than that of pro-glumide, the model compound.
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