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  • Title: Enhancement of cholesteryl ester metabolism in cultured human monocyte-derived macrophages by verapamil.
    Author: Yatsu FM, Alam R, Alam SS.
    Journal: Biochim Biophys Acta; 1985 Oct 30; 847(1):77-81. PubMed ID: 4052461.
    Abstract:
    The effect of the Ca2+ entry blocker, verapamil, on the biosynthesis of cholesterol and the metabolism of low-density lipoprotein (LDL) was studied in cultured human monocyte-derived macrophages. Addition of verapamil (50 microM) of monocyte-derived macrophages enhanced 125I-LDL and 125I-labelled acetyl-LDL binding and internalization, and increased [2-14C]acetate incorporation into cholesterol. Since higher levels of LDL and modified lipoproteins may be implicated in atherogenesis, the more efficient processing of these lipoproteins by monocyte-derived macrophages in the presence of Ca2+ blocker warrants further assessment for its potential as an antiatherogenic agent.
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