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  • Title: Antitumor polysaccharides from P. ostreatus (Fr.) Quél.: isolation and structure of a beta-glucan.
    Author: Yoshioka Y, Tabeta R, Saitô H, Uehara N, Fukuoka F.
    Journal: Carbohydr Res; 1985 Jul 01; 140(1):93-100. PubMed ID: 4053098.
    Abstract:
    We isolated an antitumor glucan (HA beta-glucan) from the neutral polysaccharide fraction (A3) of a hot-water extract of the edible mushroom P. ostreatus (Fr.) Quél. Purification was accomplished by extractions with 20% sodium chloride solution saturated with thymol and by precipitations with ethanol from dimethyl sulfoxide solution. The glucan showed marked antitumor activity at a dose of 0.1 mg/kg. It is a highly branched (1----3)-beta-glucan having an average structure represented by a pentasaccharide segment consisting of one nonreducing terminal, one 3,6-di-O-substituted, and three 3-mono-O-substituted beta-D-glucopyranosyl residues. This structure was confirmed by examining 13C-n.m.r. spectra taken at 75.46 MHz.
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