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  • Title: 131I-MIBG--a new agent in diagnosis and treatment of pheochromocytoma.
    Author: Shapiro B, Sisson JC, Eyre P, Copp JE, Dmuchowski C, Beierwaltes WH.
    Journal: Cardiology; 1985; 72 Suppl 1():137-42. PubMed ID: 4053121.
    Abstract:
    The newly developed radiopharmaceutical, 131I-metaiodobenzylguanidine (131I-MIBG), has been shown to be efficacious for the location of intra- and extra-adrenal, primary pheochromocytomas and metastatic, malignant pheochromocytomas (11.4% false-negative and 1.8% false-positive in patients with proven pheochromocytomas). Preliminary experience in selected patients with malignant pheochromocytoma suggest that therapy using large doses of 131I-MIBG results in partial tumor regression and improvement in catecholamine hypersecretion in some cases.
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