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  • Title: Complete sharing of light chain spectrotypes by murine IgM and IgG anti-streptococcal antibodies.
    Author: Perlmutter RM, Briles DE, Davie JM.
    Journal: J Immunol; 1977 Jun; 118(6):2161-6. PubMed ID: 405425.
    Abstract:
    In order to examine the diversity of antibody light chains, we have developed an analytic isoelectric focusing procedure which permits the routine analysis of L chains from antibodies raised in individual mice. We have used this technique to demonstrate that the light chains of IgM and IgG anti-group A streptococcal antibodies raised in SWR mice are probably shared. Interestingly, numerous light chain spectrotypes are shared between individual mice whose 7S antibody focusing patterns differ.
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