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  • Title: Identification of a peptide fragment from the carboxyl-terminal extension region (E-domain) of rat proinsulin-like growth factor-II.
    Author: Hylka VW, Teplow DB, Kent SB, Straus DS.
    Journal: J Biol Chem; 1985 Nov 25; 260(27):14417-20. PubMed ID: 4055782.
    Abstract:
    A fragment of the carboxyl-terminal extension region (E-peptide) of rat proinsulin-like growth factor-II has been purified from medium conditioned by cultured BRL-3A rat liver cells. The fragment, identified by microsequence analysis, was discovered in a biologically active fraction of insulin-like growth factor II (IGF-II). The fragment begins at position 117 in pro-IGF-II, two amino acids downstream from an Arg-Arg potential prohormone processing site. A synthetic analogue of the E-peptide at high concentrations stimulates [3H]thymidine incorporation in NIL8 hamster cells, raising the possibility that the E-peptide might bind with low affinity to a mitogen receptor. Peptides from the E-regions of pro-IGF-I and pro-IGF-II should be useful for development of radioimmunoassays for measurement of the somatic production of IGF-I and IGF-II, analogous to the radioimmunoassay for the insulin C-peptide.
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