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  • Title: Potassium-induced reverse transformation of cells infected with a temperature-sensitive transformation mutant virus.
    Author: Lai CN, Becker FF.
    Journal: J Cell Physiol; 1985 Nov; 125(2):259-62. PubMed ID: 4055910.
    Abstract:
    High potassium concentrations altered the morphology and the ability to grow in soft agar in 6m2 cells, a clone of rat kidney cells infected with a temperature-sensitive mutant of Moloney sarcoma virus. Approximately 60% of cells exhibited normal morphology in the presence of 94.8 mM potassium in isotonic medium at the temperature permissive for transformation, whereas 100% were normal at 72 mM potassium in hypertonic media. A significant reduction of growth in soft agar was also induced with these conditions. However, the synthesis ratio of virus-specified transforming protein to marker viral protein was not altered. Na+K+-ATPase might play a role in this reverse-transformation process.
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