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  • Title: Granulosa cell tumor of the ovary with Sertoli-Leydig cell tumor components (gynandroblastoma).
    Author: Tanaka Y, Ueda G, Komeda M, Karita T, Matsumoto K.
    Journal: Nihon Sanka Fujinka Gakkai Zasshi; 1985 Sep; 37(9):1919-23. PubMed ID: 4056537.
    Abstract:
    A rare granulosa cell tumor with Sertoli-Leydig cell tumor components (gynandroblastoma) arising in the left ovary was reported in a 63-year-old female. Microscopically, the tumor was composed predominantly of granulosa cells arranged mainly in a diffuse solid pattern, but in some areas there were a trabecular pattern and thecofibromatous stromal components. Also, well-differentiated Sertoli-Leydig cell tumor elements were present as a minor component. The tumor produced, endocrinologically, a large amount of estradiol, some androstenedione and a small amount of testosterone. The possibility that estradiol in the present tumor was produced predominantly from androstenedione via estrone was suggested by the results of an in vitro biosynthetic study.
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