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  • Title: Mucociliary transport in the human nose. Effect of topical glucocorticoid treatment.
    Author: Holmberg K, Pipkorn U.
    Journal: Rhinology; 1985 Sep; 23(3):181-5. PubMed ID: 4059802.
    Abstract:
    The effect of topical budesonide on the human mucociliary transport in the nose was investigated utilizing the saccharin-dye test in 10 healthy volunteers. Measurements were made before treatment, after a single dose and after one week continuous treatment with either placebo or active substance. The design of the study was double blind, randomized and cross-over. A single dose of placebo or budesonide did not alter the mucociliary transport as compared to pretreatment values. A trend towards decrease of mucociliary transport was noted after one week treatment with the active drug, a trend that reached statistical significance in the comparison between the 1 h value and the 1 week value.
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