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  • Title: Vitamin A and retinoic acid: induced fibroblast differentiation in vitro.
    Author: Demetriou AA, Levenson SM, Rettura G, Seifter E.
    Journal: Surgery; 1985 Nov; 98(5):931-4. PubMed ID: 4060071.
    Abstract:
    The role of vitamin A in wound healing and fibroplasia has been studied extensively in vivo but the mechanism(s) of its action has not been established. In this study the effect of vitamin A and retinoic acid on fibroblast growth and collagen accumulation in vitro was examined. Vitamin A and retinoic acid added to Balb 3T3 mouse fibroblasts in tissue culture resulted in induction of cell differentiation as manifested by a decrease in cell growth rate, enhanced collagen accumulation, and morphologic differentiation. The results of this in vitro study suggest that the stimulatory in vivo effect of vitamin A and retinoic acid on collagen accumulation and fibroplasia in healing wounds is due in a major way to fibroblast differentiation and enhanced collagen synthesis.
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