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  • Title: [Study of the growth of Streptomyces rimosus cultures during controlled biosynthesis of oxytetracycline using differential sucrose density gradient centrifugation].
    Author: Bobyleva RI, Orlova NV, Dmitrieva SV, Zaslavskaia PL.
    Journal: Antibiot Med Biotekhnol; 1985 Jun; 30(6):414-9. PubMed ID: 4062268.
    Abstract:
    The developmental characteristics of the oxytetracycline-producing organism were studied with differential centrifuging over the sucrose density gradient. It was shown that the fermentation broth of Streptomyces rimosus is divided into 7 mycelial fractions and only 2 of them are capable of biosynthesis of oxytetracycline. During controlled biosynthesis of oxytetracycline the mycelium content in these fractions was higher.
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