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  • Title: [Ultrastructural organization of the aero-hematic barrier of the lungs of laboratory animals].
    Author: Zaĭtseva KK, Simonenkova VA, Komar IuA.
    Journal: Arkh Anat Gistol Embriol; 1985 Sep; 89(9):59-66. PubMed ID: 4062582.
    Abstract:
    The ultrastructure of the aero-hematic barrier (AHB) of the lungs has been studied in the mostly used laboratory animals-mice and rats. In 2 clinically sound animals in macroscopically unchanged parts of the lungs certain disorders of rheological blood properties have been revealed, edema and focal destruction of endotheliocytes and alveolocytes of the I type, local destruction of the thin part of AHB. The changes revealed in AHB ultrastructure in intact mice and rats are in many respects similar to those developing in the lungs under various extreme influences. Therefore, a wide and thorough investigation of the lung structure in intact animals makes it possible to avoid erroneous conclusions at examining various pulmonary pathology and contributes to a correct estimation of its manifestation degree.
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