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  • Title: Spontaneous versus triggered contractions of "calcium-tolerant" cardiac cells from the adult rat ventricle.
    Author: Fabiato A.
    Journal: Basic Res Cardiol; 1985; 80 Suppl 2():83-7. PubMed ID: 4062839.
    Abstract:
    Cardiac cells were isolated from the adult rat ventricle by an enzymatic treatment. The cells considered intact were quiescent in the presence of 2.5 mM free Ca2+ but responded to an electrical stimulation by an homogeneous and brief contraction. When the procedure failed, spontaneous cyclic contractions occurred. Often they propagated as a wave from an intercalated disk, and the tension recording showed several components in each contraction. Electrical stimulation at a frequency higher than that of the spontaneous contractions induced synchronous activation with a single component of the tension. Experiments in skinned cardiac cells suggested that the spontaneous cyclic contractions observed in enzymatically separated cardiac cells are caused by a spontaneous cyclic release of Ca2+ from the sarcoplasmic reticulum (SR). This spontaneous release requires a Ca2+ overload of the SR. Its mechanism is different from that of the Ca2+-induced release of Ca2+, which is elicited by a rapid increase of [free Ca2+] at the outer surface of the SR of a previously quiescent skinned cell.
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