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  • Title: [Synthesis of peptide fragments of influenza virus A/Aichi/2/68 (H3N2) hemagglutinins].
    Author: Samukov VV, Kalashnikov VV, Ofitserov VI, Shval'e AF.
    Journal: Bioorg Khim; 1985 Aug; 11(8):1037-47. PubMed ID: 4062990.
    Abstract:
    Peptides corresponding to sequences 122-133, 136-147, and 154-164 of the heavy chain of hemagglutinin of the A/Aichi/2/68 (H3N2) influenza virus have been synthesized by stepwise elongation of the peptide chain with Boc-amino acid activated esters or by condensation of peptide blocks by DCC/HOBt-method. A coloured C-protecting group, 2-[4-(phenylazo)-benzylsulfonyl]ethyl (PSE), was used, which is convenient in purification of synthetic peptides. After removal of terminal N-and C-protecting groups the side-protecting residues were cleaved off with 1 M trifluoromethanesulfonic acid in trifluoroacetic acid containing 10% thioanisole. Crude products were purified by preparative reversed-phase liquid chromatography. Synthesized peptides were conjugated with BSA.
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