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  • Title: Geographic mappings of colorectal cancer rates: a retrospect of studies, 1974-1984.
    Author: Jansson B.
    Journal: Cancer Detect Prev; 1985; 8(3):341-8. PubMed ID: 4064058.
    Abstract:
    Geographic mapping of colorectal cancer rates revealed areas with high rates as well as areas with low rates. Comparisons between high-rate areas and areas deficient in selenium led to animal experiments that showed that selenium could reduce chemically induced intestinal tumors. A low-rate area was found to be geochemically unique with soil and water rich in potassium. This led to a series of studies indicating that elevated intracellular potassium reduces cancer risks, while elevated intracellular sodium increases the risks. Variance-reducing techniques and methods for statistical evaluation of clusters were obtained as spinoff results.
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