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  • Title: Dobutamine: a hemodynamic evaluation in pulmonary embolism shock.
    Author: Jardin F, Genevray B, Brun-Ney D, Margairaz A.
    Journal: Crit Care Med; 1985 Dec; 13(12):1009-12. PubMed ID: 4064710.
    Abstract:
    Intravenous dobutamine was used in ten patients requiring aggressive therapy for massive pulmonary embolism with circulatory failure. Except in one patient who rapidly died, a 30-min dobutamine infusion (8.3 +/- 2.7 micrograms/kg . min) increased both cardiac index (from 1.7 +/- 0.4 to 2.3 +/- 0.6 L/min . m2, p less than .001) and stroke index (from 16.6 +/- 6.7 to 21 +/- 5 ml/m2, p less than .01), and also reduced pulmonary vascular resistance. Additional hemodynamic improvement was observed until weaning from dobutamine, which was successfully completed 3.3 +/- 0.9 days after the start of infusion.
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