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  • Title: Effect of morphine-induced cortical excitation on somatosensory responses evoked in the periaqueductal grey matter.
    Author: Hernandez A, Neira S, Soto-Moyano R.
    Journal: Eur J Pharmacol; 1985 Sep 24; 115(2-3):305-8. PubMed ID: 4065211.
    Abstract:
    The somatosensory cortex responses and periaqueductal grey matter responses evoked by electric peripheral nerve stimulation were studied following topical application of 1% morphine solution to the primary somatosensory area of rat cerebral cortex. Cortically applied morphine increased the negative component of cortical potentials and enhanced the peak-to-peak amplitude of the periaqueductal grey responses. It is suggested that cortical excitation induced by morphine generates descending bioelectrical impulses modulating neuronal activity at this mesencephalic level.
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