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  • Title: Microbial conversion of daunorubicin into N-acetyl-13(S)-dihydrodaunomycin and bisanhydro-13-dihydrodaunomycinone.
    Author: Dornberger K, Hübener R, Ihn W, Thrum H, Radics L.
    Journal: J Antibiot (Tokyo); 1985 Sep; 38(9):1219-25. PubMed ID: 4066504.
    Abstract:
    By using a strain of Streptomyces willmorii, daunorubicin (daunomycin) was stereoselectively converted into N-acetyl-13(S)-dihydrodaunomycin and bisanhydro-13-dihydrodaunomycinone. The absolute stereochemistry of the new chiral center in N-acetyl-13(S)-dihydrodaunomycin was established by means of nuclear Overhauser effect measured in the 9,13-O-isopropylidene derivative.
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