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  • Title: An immunohistological study of giant-cell tumour of bone: evidence for an osteoclast origin of the giant cells.
    Author: Athanasou NA, Bliss E, Gatter KC, Heryet A, Woods CG, McGee JO.
    Journal: J Pathol; 1985 Nov; 147(3):153-8. PubMed ID: 4067733.
    Abstract:
    Using a panel of monoclonal antibodies against a variety of lymphoid and non-lymphoid antigens the immunohistological staining pattern of giant cells from a case of giant-cell tumour of bone has been compared with that of osteoclasts from the developing ends of fetal long bones. Only EBM-11, an antibody reacting with a wide spectrum of macrophages, stained both osteoclasts and giant cells; stromal cells and osteoblasts did not react. This indicates that osteoclasts and giant cells are phenotypically and presumably functionally similar. It is argued that the osteoclasts and the tumour-derived giant cells in bone are derived from a similar mononuclear precursor.
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