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  • Title: Unconjugated estriol and 15alpha-hydroxyestriol in complicated pregnancies.
    Author: Notation AD, Tagatz GE.
    Journal: Am J Obstet Gynecol; 1977 Aug 01; 128(7):747-56. PubMed ID: 406791.
    Abstract:
    Simultaneous determinations of unconjugated estriol and 15alpha-hydroxyestriol (E4) levels in maternal serum were studied serially to ascertain the relative usefulness of these estrogens as indicators of fetal welfare. Complicated pregnancies included 16 patients with pre-eclampsia and/or hypertension, six patients with severe Rh-isoimmunization, 12 patients with diabetes mellitus, of which four had vascular disease, three patients with fetal death in utero, and three twin pregnancies. Retrospective analysis failed to indicate a clinically useful role for serum E4 determinations in the evaluation of fetal welfare during high-risk pregnancies.
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