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  • Title: Role of the fungal cell wall in the granulomatous response of mice to the agents of chromomycosis.
    Author: Silva CL, Fazioli RA.
    Journal: J Med Microbiol; 1985 Dec; 20(3):299-305. PubMed ID: 4068024.
    Abstract:
    Mice were given, intraperitoneally, inocula of a cell-wall preparation and fractions thereof from Fonsecaea pedrosoi, F. compactum, Cladosporium carrioni and Phialophora verrucosum. Large doses of cell-wall preparation, with or without trypsin treatment, produced a pronounced loss of body weight, a granulomatous reaction and, sometimes, death. After extraction of the cell wall preparation with 1N NaOH, three fractions were obtained: an alkali-insoluble fraction 1; an alkali-soluble acid-insoluble fraction 2; and an alkali- and acid-soluble fraction 3. Intravenous administration showed that only fraction 1 induced a granulomatous reaction and death in mice.
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