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  • Title: Selective stimulation of venous prostaglandin E 9-ketoreductase by bradykinin.
    Author: Limas CJ.
    Journal: Biochim Biophys Acta; 1977 Jul 21; 498(1):306-15. PubMed ID: 406936.
    Abstract:
    The effects of bradykin on prostaglandin metabolism in canine mesenteric vessels were examined. Bradykinin stimulated microsomal prostaglandin synthesis in both artery and vein; this stimulation was more pronounced when [14C] hosphatidylcholine rather than [14C] arachidonate was used as the substrate for prostaglandin synthetase. This suggested that bradykinin enhanced a membrane phospholipase. In addition, bradykinin selectively stimulated prostaglandin E 9-ketoreductase activity from veins but not arteries. This may explain the finding that bradykinin induces the release of prostaglandin E compounds from arteries but prostaglandin F compounds from veins.
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