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  • Title: [Effect of sodium aurothiomalate in acute toxic hepatitis].
    Author: Korolenko TA, Shkurupiĭ VA, Subbotin VM, Iakobson GS.
    Journal: Biull Eksp Biol Med; 1977 May; 83(5):539-42. PubMed ID: 406945.
    Abstract:
    The effect of lysosomotropic agent--sodium aurothiomalate on liver damage and lysosomal changes during acute toxic hepatitis was studied. Combined administration of sodium aurothiomalete led to less extensive necrosis and to widening dystrophic areas in the hepatic parenchyma. Solubilization of the acid RNA-ase activity was decreased, and nonsedimentable activities of beta-galactosidase, cathepsin D were the same as in acute CCl4-hepatitis.
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