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  • Title: Intramembranous particle patches in myelin-deficient rat axons.
    Author: Rosenbluth J.
    Journal: Neurosci Lett; 1985 Nov 20; 62(1):19-24. PubMed ID: 4069451.
    Abstract:
    Focal accumulations of E-face intramembranous particles occur in spinal cord axons of myelin-deficient rat mutants. These resemble nodal particles and, like them, may represent voltage-sensitive sodium channels. It is proposed that axonal activity at these foci could increase extracellular potassium to the point of triggering activity in adjacent axons. Rapid spread of such potassium-induced activity among bare axons could underlie the seizures and other neurological abnormalities that develop in this mutant. A similar mechanism may account for the paroxysmal attacks sometimes seen in multiple sclerosis.
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