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  • Title: [Change in the metabolism of 7,12-dimethylbenz(a)anthracene under the influence of vitamin A].
    Author: Kkhandudzha KL, Esakova TD, Semin BK, Petrusevich IuM, Tarusov BN.
    Journal: Biull Eksp Biol Med; 1977 May; 83(5):579-82. PubMed ID: 406946.
    Abstract:
    The in vitro metabolism of 7,12-dimethylbenz(a)anthracene in its incubation with the liver microsomes, the liver and mammary gland homogenates of rats, kept on vitamin A-enriched diet, was studied. Vitamin A inhibited the formation of lipophilic metabolites and increased the generation of water-soluble metabolites. The amount of lipophilic metabolites extracted from the microsomes and the liver and mammary gland homogenates were decreased by a factor of 2.2 and 5, respectively. The amount of unmetabolized DMBA in the liver microsomes was the same in control and experimental animals.
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