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  • Title: Increased low-affinity 3H-spiroperidol binding to rat cortical membranes after chronic antidepressant treatments.
    Author: Antkiewicz-Michaluk L, Rokosz-Pelc A, Vetulani J.
    Journal: Pol J Pharmacol Pharm; 1985; 37(3):317-23. PubMed ID: 4070080.
    Abstract:
    Looking for receptor correlates of increased motor response to dopaminergic stimulation in rats after antidepressant treatments, we measured specific 3H-spiroperidol binding to membranes from various brain ureas in rats receiving chronically electroconvulsive shock (ECS), imipramine or trazodone. In all groups the low-affinity 3H-spiroperidol binding (KD approximately 3 nM) was increased in the cortex, but not in the subcortical areas.
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