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  • Title: [Can blockade of presynaptic adrenergic beta receptors explain the antihypertensive effects of propranolol?].
    Author: Montastruc JL, Montastruc P.
    Journal: C R Seances Acad Sci D; 1979 Jul 02; 289(1-2):37-40. PubMed ID: 40705.
    Abstract:
    Pretreatment with 6-hydroxydopamine abolished the antihypertensive effects of intravenously and intracisternally administered dl-propranolol in dogs with acute neurogenic hypertension. These results show that the anti-hypertensive action of this drug is dependant on the integrity of central catecholaminergic neurones and suggest an action on presynaptic bêta-adrenoceptors.
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