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  • Title: Differential effects of calcium channel antagonists on histamine and pentagastrin-stimulated gastric acid secretion in the rat.
    Author: Bouclier M, Spedding M.
    Journal: Agents Actions; 1985 Sep; 16(6):491-5. PubMed ID: 4072828.
    Abstract:
    Different calcium channel antagonists have been assessed for their ability to inhibit gastric acid secretion in rats. Whereas verapamil, diltiazem and cinnarizine inhibited pentagastrin-induced gastric acid secretion but not histamine-induced secretion, nifedipine selectively inhibited the stimulant effect of histamine. In contrast, the vasodilator hydralazine had non-selective effects. These findings indicate that calcium-antagonists may have differential effects against different secretagogues and these effects are not simply related to hypotensive effects.
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