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  • Title: [Glomerulonephritis secondary to ventriculo-atrial shunts].
    Author: Morcamp D, Bercoff E, Ducastelle T, Godin M, Fillastre JP, Bourreille J.
    Journal: Ann Med Interne (Paris); 1985; 136(2):109-13. PubMed ID: 4073695.
    Abstract:
    The authors report the case of a 45 year old man who had undergone a ventriculo-atrial CSF shunt procedure 5 years previously for normal pressure hydrocephalus and who had several unexplained episodes of infection over a 12 months period and has now developed a mixed nephrotic syndrome associated with a septicaemia. Corynebacterium commensale and Staphylococcus epidermis were isolated from the valve culture. Ablation of the valve resulted in clinical cure with minimal functional renal sequellae. The initial renal biopsy showed type I proliferative glomerulonephritis with subendothelial deposits of complement and immunoglobulins, which did not completely regress after 3 months' evolution. The serum complement fractions suggested activation of the alternate pathway and the possible pathogenic role of circulating immune complexes.
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