These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Proton gradient-coupled uphill transport of glycylsarcosine in rabbit renal brush-border membrane vesicles.
    Author: Miyamoto Y, Ganapathy V, Leibach FH.
    Journal: Biochem Biophys Res Commun; 1985 Nov 15; 132(3):946-53. PubMed ID: 4074356.
    Abstract:
    An inward-directed proton gradient energizes the transport of intact glycylsarcosine against a concentration gradient in rabbit renal brush-border membrane vesicles. Dissipation of the proton gradient abolishes the uphill transport. Generation of an inside-negative membrane potential nearly doubles the intravesicular concentration of the dipeptide at the peak of the overshoot without altering the equilibrium value. These data provide direct evidence for peptide-proton cotransport in the renal brush-border membrane.
    [Abstract] [Full Text] [Related] [New Search]