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  • Title: Effect of cilostazol, a new antithrombotic drug, on an experimental model of peripheral circulation insufficiency.
    Author: Kawamura K, Fujita S, Tani T, Kimura Y.
    Journal: Arzneimittelforschung; 1985; 35(7A):1154-6. PubMed ID: 4074428.
    Abstract:
    Acute arterial obstruction in hind limb was experimentally induced by intra-arterial injection of sodium laurate saline solution in mongrel dogs, and the inhibitory action of cilostazol (6-[4-(1-cyclohexyl-1H-tetrazol-5-yl)butoxy]- 3,4-dihydro-2(1H)-quinolinone, OPC-13013) on ulcer formation was studied. Cilostazol at oral doses of 10 and 30 mg/kg inhibited ulcer development. Cilostazol inhibited decrease in skin temperature in obstructed hindlimbs in a dose-dependent manner. Cilostazol also inhibited increase of plasma aldolase, creatine phosphokinase and glutamic oxalacetic transaminase activities, presumably due to necrosis of the skeletal muscle.
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