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  • Title: Long-term effect of cilostazol on cerebral blood flow in chronic cerebral infarction.
    Author: Kobayashi S, Yamaguchi S, Katsube T, Kitani M, Okada K, Tsunematsu T.
    Journal: Arzneimittelforschung; 1985; 35(7A):1193-7. PubMed ID: 4074433.
    Abstract:
    The effect of the oral administration of a new vasodilator, cilostazol (6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H)-quinolinone, OPC-13013) on cerebral circulation in chronic cerebral infarction was studied by the 133Xenon inhalation method. Mean regional cerebral blood flow (rCBF) was increased in 6 out of 14 cases after 2 weeks of treatment. Hemispheric rCBF was significantly increased in both the affected and non-affected sides (10.8 and 13.4%, respectively) (p less than 0.05) without causing a change in blood pressure.
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