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  • Title: [Acid glycosidases of normal cattle lymphocytes and in chronic lympholeukemia].
    Author: Preobrazhenskaia ME, Gevorkian NM.
    Journal: Biull Eksp Biol Med; 1985 Dec; 100(12):698-701. PubMed ID: 4074871.
    Abstract:
    The activity of five acid glycosidases was determined in lymphocytes from normal animals and animals with chronic lymphocytic leukemia. It was shown that alpha-D-mannosidase activity in leukemic lymphocytes was 5 times lower (p less than less than 0.001) and alpha-D-glucosidase activity was 2 times lower (p less than 0.01) than in normal controls. The progress of the disease and the increase in leukocyte count were accompanied by the decrease in alpha-D-mannosidase activity. No differences have been found in alpha-D-mannosidase properties (thermostability, Km values, ZnSl2 activation) in normal and leukemic lymphocytes.
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