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  • Title: Aspects of bronchial reactivity to prostaglandins and aspirin in asthmatic patients.
    Author: Pasargiklian M, Bianco S, Allegra L, Moavero NE, Petrigni G, Robuschi M, Grugni A.
    Journal: Respiration; 1977; 34(2):78-91. PubMed ID: 407642.
    Abstract:
    The behaviour of bronchial reactivity to PGF2alpha was studied in asthmatic patients under various experimental conditions. Premedication with aminophylline, i.v., and, to a lesser extent, with DSCG afforded a partial protection, while beclomethasone dipropionate was inactive under this point of view. Diftalone, a new non-steroid anti-inflammatory agent, was well tolerated in 9 aspirin-intolerant asthmatic patients, and did not modify the bronchial response to PGF2alpha which was found to be generally lower then that of other aspirin-tolerant asthmatic patients. PGE 1-2 and DSCG prevented the bronchospasm induced by inhalation or ingestion of acetylsalicylic acid in a small group of patients. Good protection was also reached with PGE1-2 in the exercise-induced bronchospasm.
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