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  • Title: [Characteristics of the effect of piracetam on liver-mitochondrial respiration in intact and gonadectomized rats of both sexes].
    Author: Terekhina AI, Agureev AP.
    Journal: Farmakol Toksikol; 1985; 48(5):81-4. PubMed ID: 4076427.
    Abstract:
    It has been established in experiments on rats that subcutaneous administration of piracetam for 6 days in a daily dose of 100 mg/kg produces in intact but not in gonadectomized animals the following alterations in the system of oxidation and energetic coupling of liver mitochondria: a decrease in the magnitude of the respiratory control according to Chance, elevation of the rate of oxidation of NAD+-dependent substrates, a decrease in the stimulation of the rates of substrate oxidation by a disconnector, a rise of the rate of exogenous NADH oxidation by the amytal-antimycin A-resistant pathway. The action of piracetam described is pronounced to a greater degree in females than in males.
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