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  • Title: Enterohepatic recycling of N-nitrosodiethanolamine in rats.
    Author: Bonfanti M, Castelli MG, Fanelli R, Airoldi L.
    Journal: Food Chem Toxicol; 1985 Nov; 23(11):1011-3. PubMed ID: 4076928.
    Abstract:
    N-Nitrosodiethanolamine (NDELA) was administered to rats whose bile was drained directly into the duodenum of a second group of animals, in which the natural bile flow was ligated, thus simulating enterohepatic circulation. The presence of NDELA and its metabolite N-(2-hydroxyethyl)-N-(carboxymethyl)nitrosamine in the urine of the 'bile-recipient' rats indicated that NDELA was first excreted into the bile and then reabsorbed from the duodenum into the bloodstream. The enterohepatic recycling of NDELA may be a factor in the compound's known hepatocarcinogenicity.
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