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  • Title: Metabolism of an industrial uranium trioxide dust after deposition in the rat lung.
    Author: Stradling GN, Stather JW, Ellender M, Sumner SA, Moody JC, Towndrow CG, Hodgson A, Sedgwick D, Cooke N.
    Journal: Hum Toxicol; 1985 Nov; 4(6):563-72. PubMed ID: 4077068.
    Abstract:
    UNLABELLED: Uranium trioxide, produced industrially, was administered to rats either by inhalation or direct injection of an aqueous suspension into the lungs. THE RESULTS: show that uranium was cleared rapidly from the lungs, mainly to the blood; show that distribution of uranium among body tissues, and the fraction of the systemic content excreted in urine, was similar to that obtained for other transportable hexavalent uranium compounds; suggest that urine monitoring data would be of more value than lung radioactivity counting measurements for assessing occupational human exposure; indicate that for setting exposure limits by inhalation the uranium trioxide should be considered a highly transportable compound. Thus intakes by workers should be restricted to those recommended for short-term exposures and not those based on an annual limit.
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