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  • Title: In vivo experiments with powder charcoal haemoperfusion (filmadsorber) in a pig model of hepatic failure.
    Author: van Berlo AM, de Groot GH, Schalm SW, Jansen PP, de Vries EH, Fick T, Reuvers C, Boks AL.
    Journal: Int J Artif Organs; 1985 Nov; 8(6):335-40. PubMed ID: 4077293.
    Abstract:
    The filmadsorber, an experimental haemoperfusion column containing activated powder charcoal embedded in a colloidal film, has been tested in pigs with ischaemicnecrosis of the liver. Haemoperfusion with a flow of 200 ml/min was performed for a duration of 4 to 6 hours. Bile acid clearances varied between +/- 52 ml/min (1st hour) and +/- 23 ml/min (6th hour). Clearances for aromatic amino acids were initially even higher (phenylalanine 115, tyrosine 112 and methionine 46 ml/min). No ammonia was removed. Side-effects were minimal, although platelets fell 24 +/- 15%. We conclude that haemoperfusion with the filmadsorber is well tolerated and associated with high clearances for bile acids and some amino acids, particularly in the first hours of treatment.
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