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  • Title: Contrast enhancement of the liver and blood. Nonionic versus ionic contrast media in the pig.
    Author: Jensen LI, Golman K, Nyman U, Dean PB.
    Journal: Invest Radiol; 1985 Dec; 20(9):989-94. PubMed ID: 4077451.
    Abstract:
    The contrast enhancement of low-osmolality (iohexol) and high-osmolality (diatrizoate) contrast media was compared in 18 pigs following intravenous bolus administration. Liver and blood attenuation and blood sample iodine concentration were measured during the first 3 minutes after injection. Iohexol produced a significantly higher contrast enhancement in the blood during the period from 0.5 to 3 minutes after injection. Diatrizoate produced a significantly higher contrast enhancement in the liver during the period from 9 to 30 minutes after injection. The greater contrast enhancement of iohexol during the acute phase should be advantageous in dynamic CT.
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