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  • Title: Eosinophilic histiocytosis: a variant form of lymphomatoid papulosis or a disease sui generis?
    Author: McLeod WA, Winkelmann RK.
    Journal: J Am Acad Dermatol; 1985 Dec; 13(6):952-8. PubMed ID: 4078102.
    Abstract:
    Five patients are reported on whose clinical skin disease consisted of polymorphous papulonodular lesions healing with a depigmented scar. Although all cases had been termed lymphomatoid papulosis after clinical or histologic examination, the lesions consisted principally of masses of histiocytes and eosinophils. Individual lesions healed spontaneously or with minimal treatment, but the chronic course of disease was not altered by any therapy used. Follow-up 3 to 17 years later indicated persistent or recurrent disease, and one patient died of histiocytic malignancy. Eosinophilic histiocytosis is the microscopic picture of an unusual group of patients with chronic papulonodular necrotic skin disease that may deserve to be considered a disease pattern per se.
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