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  • Title: Optometric implications of systemic drug therapy.
    Author: Canon SH.
    Journal: J Am Optom Assoc; 1985 Nov; 56(11):843-4. PubMed ID: 4078206.
    Abstract:
    It is important for eye care professionals to be aware of the ocular toxicities of systemic medications. Optimally, there should be a comprehensive eye and vision baseline before administration of certain drug therapies so that the effect of treatment can be monitored. This article summarizes the optometric implications of treatment with the phenothiazines, antimalarials, cortocosteroids, topical steroid therapy, digitalis glycosides, diuretics, and oral contraceptives (OCs). These side effects can range from mild, intermittent blurred vision to irreversible loss of visual acuity and visual field. The exact nature of side effects associated with OC us remains unclear. However, the potential for severe toxicity, including retrobulbar or optic neuritis and papilledema secondary to pseudotumor cerebri, has been established. Retinal toxicity may result from damage to retinal vasculature. Central or branch vein or artery occlusion as well as perimacular edema have been noted. Ocular toxicity associated with these preparations is an indication that the drug therapy should be altered.
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